Description

Ursodeoxycholic Acid-24-13C is a stable isotope-labeled analog of the primary therapeutic bile acid, ursodeoxycholic acid (UDCA). This compound, with a carbon-13 atom at the 24-position, is an essential tool for advanced pharmaceutical research and metabolic studies, enabling precise quantification and tracing of UDCA and its metabolites. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in pharmacokinetics, drug metabolism, and the development of novel therapies for cholestatic liver diseases.

Application

• Isotope Dilution Mass Spectrometry (IDMS): Serves as a critical internal standard for the accurate and sensitive quantification of endogenous UDCA levels in biological matrices (e.g., serum, bile, tissue) via LC-MS/MS or GC-MS.
• Pharmacokinetic and Metabolic Tracing Studies: Used to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of UDCA in preclinical and clinical research.
• Drug Development and Bioanalysis: Essential in the development and validation of bioanalytical methods for new UDCA-based pharmaceutical formulations and generics.
• Mechanistic Research: Facilitates studies on the molecular mechanisms of UDCA's hepatoprotective, anti-apoptotic, and anti-inflammatory effects in liver disease models.
• Diagnostic Assay Development: Employed in the calibration and standardization of clinical diagnostic assays measuring bile acid profiles.
• Quality Control Reference Standard: Acts as a high-purity certified reference material for quality control in pharmaceutical manufacturing of UDCA active pharmaceutical ingredient (API).

Basic Information

Product Name	Ursodeoxycholic Acid-24-13C
CAS No.	63296-46-8
Molecular Formula	C24H4013CO4
Molecular Weight	395.58 g/mol (for 13C1 isotopologue)
Synonyms	UDCA-24-13C; 24-13C-Ursodeoxycholic Acid; 3α,7β-Dihydroxy-5β-cholan-24-oic-24-13C Acid; Ursodiol-24-13C; (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-24-13C Acid; 24-13C-UDCA; Cholac-24-13C; Deursil-24-13C
EINECS	Contact for details

Quality Control

Our Ursodeoxycholic Acid-24-13C is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥99 atom % 13C), chemical purity (by HPLC), and confirming identity and absence of significant impurities. We support compliance with relevant GMP and ISO guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Presence of M+1 ion peak confirmed
Isotopic Enrichment	≥99 atom % 13C
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chemical Purity (HPLC)	≥98.5%
Specific Optical Rotation	+59° to +62° (c=1, EtOH)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.