Description

Boc-1,2-cis-Achec-Oh is a protected amino acid derivative, specifically a cis-configured cyclic amino acid with a tert-butoxycarbonyl (Boc) protecting group. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic agents, particularly in the fields of protease inhibitors and constrained peptide drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce a constrained, cis-configured amino acid residue.
• Protease Inhibitor Design: Serves as a core structural component in the design of inhibitors for various enzymes like HIV protease or HCV protease.
• Peptidomimetics: Enables the creation of metabolically stable peptide analogs with enhanced bioavailability and receptor selectivity.
• Chemical Biology Research: Employed as a tool compound to study protein-protein interactions and enzyme mechanisms.
• Academic & Industrial R&D: Supports synthetic chemistry programs in universities and corporate R&D laboratories.

Basic Information

Product Name	Boc-1,2-cis-Achec-Oh
CAS No.	63216-52-4
Molecular Formula	C₁₁H₁₉NO₄
Molecular Weight	229.27 g/mol
Synonyms	(1S,2R)-1-[(tert-Butoxycarbonyl)amino]-2-cyclohexanecarboxylic Acid; (1S,2R)-2-(Boc-amino)cyclohexane-1-carboxylic Acid; Boc-cis-ACHC-OH; Boc-(1S,2R)-ACHC-OH; (1S,2R)-1-(Boc-amino)cyclohexane-2-carboxylic Acid; tert-Butyl ((1S,2R)-2-carboxycyclohexyl)carbamate
EINECS	Contact for details

Quality Control

Our Boc-1,2-cis-Achec-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (typically ≥98%), enantiomeric excess, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.