Description

p-Aminophenylacetyl-Thr-Lys-Pro-Arg is a synthetic peptide derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a crucial building block and intermediate for the synthesis of novel therapeutic agents, particularly in the fields of oncology and targeted drug delivery. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in peptide-based drug discovery. The high-purity grade of this material ensures reliable performance in sensitive biochemical applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted peptide-drug conjugates (PDCs) and other bioactive molecules.
• Protease Substrate Analog: Used in biochemical research to study enzyme kinetics and inhibition, particularly for thrombin and related serine proteases.
• Drug Discovery Scaffold: Serves as a core structure for medicinal chemistry optimization to develop new candidates with improved pharmacokinetic properties.
• Bioconjugation Linker: The p-aminophenylacetyl moiety facilitates site-specific conjugation to antibodies, proteins, or other targeting ligands.
• In-vitro Diagnostic Reagent: Component in assay kits for detecting specific enzymatic activity in clinical and research settings.
• Academic Research: Employed in university and institutional labs for fundamental studies on peptide structure-activity relationships (SAR).

Basic Information

Product Name	p-Aminophenylacetyl-Thr-Lys-Pro-Arg
CAS No.	63147-94-4
Molecular Formula	C30H48N10O7
Molecular Weight	660.77 g/mol
Synonyms	p-Aminophenylacetyl-Threonyl-Lysyl-Prolyl-Arginine; 4-Aminophenylacetyl-TKP-R; H-Thr-Lys-Pro-Arg-4-aminophenylacetamide; APPA-TKP-R; Arg-Pro-Lys-Thr-4-aminophenylacetyl; Thrombin Inhibitor Peptide Derivative; Benzeneacetamide, 4-amino-N-[1-[[1-[1-[[(4-aminophenyl)acetyl]amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]carbonyl]-4-(aminomethyl)butyl]-; (p-Amino-Phe)-Thr-Lys-Pro-Arg
EINECS	Contact for details

Quality Control

Our p-Aminophenylacetyl-Thr-Lys-Pro-Arg is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet general research-grade specifications, we can discuss custom synthesis to align with specific project requirements, including higher purity grades for preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment after opening to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.