Description

H-Glu(Obzl)-Nh2 Hcl is a protected glutamic acid derivative, specifically the benzyl ester hydrochloride salt of glutamine. This compound serves as a crucial building block (amino acid derivative) in the synthesis of complex peptides and pharmaceutical intermediates. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A key raw material in the solid-phase and solution-phase synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in academic and industrial R&D for studying enzyme-substrate interactions, metabolic pathways, and protein engineering.
• Peptide Library Construction: Essential for creating diverse peptide libraries used in drug discovery, screening for biological activity, and epitope mapping.
• Protecting Group Chemistry: The benzyl (Obzl) ester group provides selective protection for the γ-carboxyl side chain of glutamic acid during multi-step organic syntheses.
• Conjugate and Prodrug Synthesis: Employed in the design and synthesis of antibody-drug conjugates (ADCs) and prodrugs where controlled release of glutamic acid or its analogs is required.

Basic Information

Product Name	H-Glu(Obzl)-Nh2 Hcl
CAS No.	63091-89-4
Molecular Formula	C₁₂H₁₇ClN₂O₄
Molecular Weight	288.73 g/mol
Synonyms	L-Glutamine, N2-benzyloxycarbonyl-, γ-benzyl ester hydrochloride; Z-Gln-OBzl HCl; N-Carbobenzoxy-L-glutamine γ-benzyl ester hydrochloride; Cbz-L-glutamine γ-benzyl ester hydrochloride; Nα-Cbz-L-glutamine γ-benzyl ester hydrochloride; (S)-2-(((Benzyloxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanamide hydrochloride; Glutamine derivative Z-Gln-OBzl·HCl
EINECS	Contact for details

Quality Control

Our H-Glu(Obzl)-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and GMP applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Specific range provided on COA
Chiral Purity	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.