Description

Boc-L-Propargylglycine Dcha Salt is a high-purity, protected amino acid derivative widely used in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring a propargyl-functionalized building block with orthogonal protecting group strategies. It is particularly valuable in the pharmaceutical and biotechnology sectors for applications such as peptide synthesis, bioconjugation via click chemistry, and the development of novel therapeutic agents. The Dicyclohexylamine (DCHA) salt form enhances its stability and handling properties for industrial-scale processes.

Application

• Peptide Synthesis: Serves as a key intermediate for incorporating propargylglycine residues into custom peptides and peptidomimetics.
• Bioconjugation & Click Chemistry: The alkyne side chain enables efficient, site-specific labeling of biomolecules (proteins, antibodies, oligonucleotides) via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Pharmaceutical Intermediates: Used in the research and development of novel drug candidates, including enzyme inhibitors and targeted therapies.
• Chemical Biology Probes: Acts as a metabolic precursor or building block for creating activity-based probes to study enzyme function and protein interactions.
• Material Science: Employed in the synthesis of functionalized polymers and smart materials with tailored biological activity.
• Academic & Industrial R&D: A critical reagent for exploring new synthetic methodologies and bioorthogonal reactions in laboratory settings.

Basic Information

Item	Details
Product Name	Boc-L-Propargylglycine Dcha Salt
CAS No.	63039-49-6
Molecular Formula	C₂₁H₃₆N₂O₄
Molecular Weight	380.53 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-propargylglycine dicyclohexylamine salt; Boc-L-Propargylglycine DCHA Salt; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]pent-4-ynoic acid - N-cyclohexylcyclohexanamine (1:1); N-α-Boc-L-propargylglycine dicyclohexylammonium salt; Boc-Propargyl-Gly-OH·DCHA; BOC-Pra(DCHA); N-tert-Butoxycarbonyl-L-propargylglycine dicyclohexylamine salt
EINECS	Contact for details

Quality Control

Our Boc-L-Propargylglycine Dcha Salt is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.