Description

(S)-n-Boc-Propargylglycine is a high-purity, non-natural amino acid derivative featuring a propargyl side chain and a tert-butoxycarbonyl (Boc) protecting group on the amine. This compound is a critical chiral building block in organic synthesis and medicinal chemistry, enabling the introduction of a bioorthogonal alkyne functionality for click chemistry applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries for the development of novel therapeutics, peptide mimetics, and chemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and peptide-based therapeutic development.
• Peptide Chemistry & Modification: Used to incorporate an alkyne handle into peptide chains for subsequent site-specific bioconjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Chemical Biology & Probe Development: Enables the labeling and study of biological systems through bioorthogonal reactions, facilitating target identification and validation.
• Agrochemical Research: Serves as a building block for creating novel active ingredients with specific chiral configurations.
• Material Science: Potential use in the synthesis of functionalized polymers and advanced materials with tailored properties.
• Academic & R&D: A valuable reagent for methodological studies in asymmetric synthesis and the development of new catalytic processes.

Basic Information

Product Name	(S)-n-Boc-Propargylglycine
CAS No.	63039-48-5
Molecular Formula	C₁₀H₁₅NO₄
Molecular Weight	213.23 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid; Boc-L-Propargylglycine; (S)-2-(Boc-amino)pent-4-ynoic acid; Boc-Propargylglycine-OH; (S)-Boc-Propargylglycine; N-Boc-L-Propargylglycine; N-α-Boc-L-Propargylglycine; L-Propargylglycine, N-Boc-
EINECS	Contact for details

Quality Control

Our (S)-n-Boc-Propargylglycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistent performance. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and other critical parameters are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.