Description

(R)-n-Boc-Propargylglycine is a high-purity, non-natural amino acid derivative featuring a chiral center and a propargyl side chain protected by a tert-butoxycarbonyl (Boc) group. This compound is a critical chiral building block in modern pharmaceutical research and peptide chemistry, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and advanced materials sectors for developing novel therapeutics and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a propargyl-functionalized, Boc-protected amino acid residue for click chemistry applications.
• Chemical Biology Probes: Serves as a precursor for labeling reagents and activity-based probes, leveraging the alkyne group for bioorthogonal conjugation (e.g., CuAAC click reactions).
• Organocatalyst & Ligand Development: Employed in the research and development of novel chiral catalysts and ligands for asymmetric synthesis.
• Material Science: A building block for functionalized polymers and smart materials where specific chirality and reactive handles are required.

Basic Information

Product Name	(R)-n-Boc-Propargylglycine
CAS No.	63039-46-3
Molecular Formula	C₁₀H₁₅NO₄
Molecular Weight	213.23 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid; (R)-Boc-Propargylglycine; (R)-Boc-Pra-OH; (R)-N-Boc-2-amino-4-pentynoic acid; (R)-N-(tert-Butoxycarbonyl)-2-amino-4-pentynoic acid; Boc-D-Propargylglycine; (R)-N-Boc-Propargylglycine; (2R)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]pent-4-ynoic acid
EINECS	Contact for details

Quality Control

Our (R)-n-Boc-Propargylglycine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.