Description

Butanamide, 2-Amino-3,3-Dimethyl-, (2S)- CAS NO 62965-57-5 is a chiral, non-proteinogenic amino acid derivative characterized by its unique gem-dimethyl substitution on the β-carbon. This compound is a high-value chiral building block prized for its role in introducing steric hindrance and conformational rigidity into synthetic targets. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, peptide mimetics, and advanced intermediates where structural control is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in peptide-based therapeutics and enzyme inhibitors.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides that require specific spatial orientation for optimal activity.
• Peptide Mimetics & Conformationally Restricted Analogs: Essential for constructing peptide backbones with enhanced metabolic stability and target selectivity.
• Asymmetric Synthesis Catalyst Ligand: Serves as a precursor for chiral ligands and auxiliaries used in enantioselective catalysis.
• Biochemical Research: Employed in studies of enzyme mechanisms and as a standard in analytical method development for chiral separation.
• Fine Chemical Production: A building block for complex, high-value specialty chemicals requiring precise stereochemistry.

Basic Information

Product Name	Butanamide, 2-Amino-3,3-Dimethyl-, (2S)-
CAS No.	62965-57-5
Molecular Formula	C6H14N2O
Molecular Weight	130.19 g/mol
Synonyms	(2S)-2-Amino-3,3-dimethylbutanamide; L-tert-Leucinamide; (S)-2-Amino-3,3-dimethylbutyramide; (S)-tert-Leucinamide; (S)-2-Amino-3,3-dimethylbutanamide; H-Tle-NH2; (S)-3,3-Dimethyl-2-aminobutanamide; tert-Leucinamide
EINECS	Contact for details

Quality Control

Our production of (2S)-2-Amino-3,3-dimethylbutanamide adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure identity, potency, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor quality systems to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.