Description

n-Boc-L-tert-Leucine is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block, offering superior steric protection for the tert-leucine side chain during complex coupling reactions. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel therapeutic peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediates: Key raw material in the synthesis of peptide-based drugs and bioactive molecules.
• Peptide Synthesis: Serves as a crucial N-α-protected amino acid for Solid-Phase Peptide Synthesis (SPPS) and solution-phase methodologies.
• API Development: Used in research and production of Active Pharmaceutical Ingredients (APIs) requiring the incorporation of the structurally unique tert-leucine residue.
• Bioconjugation & Linker Chemistry: Employed in the design of peptide-drug conjugates and diagnostic agents.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions and developing enzyme inhibitors.
• Custom Synthesis: Building block for contract research organizations (CROs) and CDMOs producing bespoke peptides for clients.

Basic Information

Product Name	n-Boc-L-tert-Leucine
CAS No.	62965-35-9
Molecular Formula	C11H21NO4
Molecular Weight	231.29 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoic acid; Boc-L-tert-leucine; Boc-Tle-OH; N-(tert-Butoxycarbonyl)-L-tert-leucine; N-Boc-L-tert-leucine; N-α-Boc-L-tert-leucine; (S)-2-(tert-Butoxycarbonylamino)-3,3-dimethylbutyric acid; L-tert-Leucine, N-Boc- derivative
EINECS	Contact for details

Quality Control

Our n-Boc-L-tert-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	-20.0° to -24.0° (c=1 in MeOH)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.