Description

(6S)-Tetrahydro-L-Biopterin CAS NO 62961-57-3 is the biologically active, fully reduced form of L-Biopterin, serving as an essential cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. This high-purity compound is critical for research and production processes requiring a stable and reliable source of the native enzyme cofactor. It is primarily utilized by the pharmaceutical, biotechnology, and advanced research sectors for applications in enzymology, metabolic studies, and the development of therapeutic agents.

Application

• Pharmaceutical Research & Development: Essential cofactor for studying enzyme kinetics and mechanisms of phenylalanine, tyrosine, and tryptophan hydroxylases.
• Therapeutic Agent Synthesis: Used in the production and formulation of compounds targeting metabolic disorders related to biopterin metabolism.
• Diagnostic Reagent Manufacturing: A key component in enzymatic assay kits for the detection and quantification of amino acids and neurotransmitters.
• Cell Culture & Biochemistry: Supports research in nitric oxide signaling pathways and cellular metabolism studies.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical and research laboratories.
• Enzyme Stabilization: Employed to maintain the activity of sensitive hydroxylase enzymes in vitro.

Basic Information

Item	Details
Product Name	(6S)-Tetrahydro-L-Biopterin
CAS No.	62961-57-3
Molecular Formula	C9H15N5O3
Molecular Weight	241.25 g/mol
Synonyms	(6R)-5,6,7,8-Tetrahydro-L-biopterin; (6R)-BH4; (6R)-Tetrahydrobiopterin; Sapropterin (active form); 6R-THBP; L-erythro-5,6,7,8-Tetrahydrobiopterin; (6R)-5,6,7,8-Tetrahydro-L-erythro-biopterin
EINECS	Contact for details

Quality Control

Our (6S)-Tetrahydro-L-Biopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to minimize moisture exposure. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: -16° to -20° (c=1 in 0.1N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.