Description

Z-D-Pro-Nh2 is a protected amino acid derivative, specifically the Z-protected form of D-prolinamide, with CAS No. 62937-47-7. This chiral building block is essential for the synthesis of complex peptides and peptidomimetics, offering critical control over stereochemistry and molecular structure. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis laboratories for developing active pharmaceutical ingredients (APIs), diagnostic agents, and advanced biochemical tools.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based therapeutics and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-proline configuration into peptide chains.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for targeted delivery.
• Chemical Biology Research: Employed in the design and study of peptidomimetics and enzyme substrates/inhibitors.
• Asymmetric Synthesis: Acts as a chiral auxiliary or building block in the synthesis of non-peptide compounds requiring specific stereocenters.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for peptide analysis.

Basic Information

Product Name	Z-D-Pro-Nh2
CAS No.	62937-47-7
Molecular Formula	C₁₃H₁₆N₂O₃
Molecular Weight	248.28 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-D-prolinamide; (R)-1-((Benzyloxy)carbonyl)pyrrolidine-2-carboxamide; Z-D-Pro-NH₂; Cbz-D-Pro-NH₂; N-Carbobenzoxy-D-prolinamide; D-Proline, N-[(phenylmethoxy)carbonyl]-, amide; (R)-2-(((Benzyloxy)carbonyl)carbamoyl)pyrrolidine; Benzyl (R)-2-carbamoylpyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our Z-D-Pro-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.