Description

Cefoperazone is a broad-spectrum, third-generation cephalosporin antibiotic belonging to the cephamycin class. Its primary value lies in its potent activity against a wide range of Gram-positive and Gram-negative bacteria, including many Pseudomonas aeruginosa strains. This makes it a critical active pharmaceutical ingredient (API) for the formulation of injectable antibiotics. Pharmaceutical manufacturers and research institutions globally require high-purity Cefoperazone CAS NO 62893-19-0 for developing and producing effective antimicrobial therapies.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic formulations.
• Hospital & Clinical Use: Formulated for the treatment of severe infections such as septicemia, pneumonia, and intra-abdominal infections.
• Veterinary Medicine: Used in the development of antibiotics for treating bacterial infections in animals.
• Research & Development: Serves as a reference standard and key intermediate in microbiological and pharmacological research.
• Combination Therapies: Often used in combination with β-lactamase inhibitors like sulbactam to enhance efficacy against resistant organisms.

Basic Information

Product Name	Cefoperazone
CAS No.	62893-19-0
Molecular Formula	C25H27N9O8S2
Molecular Weight	645.67 g/mol
Synonyms	Cefoperazone Sodium; Cefobid; T-1551; Cefoperazone Acid; (6R,7R)-7-[[(2R)-2-[[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
EINECS	263-607-1

Quality Control

Our Cefoperazone is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP, EP, and JP. Every batch undergoes comprehensive analytical testing including HPLC for assay and related substances, residual solvent analysis, and microbiological examination. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure traceability and confirm specification adherence.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
pH (1% Solution)	3.0 - 5.0
Specific Optical Rotation	-30° to -40°
Bacterial Endotoxins	< 0.10 EU/mg
Microbial Enumeration	Meets EP/USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.