Description

N1,N3-Bis(1,3-Dihydroxypropan-2-Yl)-5-(2-Hydroxypropanamido)-2,4,6-Triiodoisophthalamide is a high-purity, non-ionic iodinated compound primarily utilized as a key intermediate in the synthesis of modern X-ray contrast media. Its molecular structure is engineered to provide excellent water solubility and low osmolality, which are critical for patient safety and diagnostic efficacy. This product is essential for manufacturers in the pharmaceutical industry, particularly those developing and producing advanced contrast agents for computed tomography (CT) and angiography.

Application

• Pharmaceutical Intermediate: Primary building block for synthesizing non-ionic, low-osmolar iodinated contrast agents.
• Contrast Media Production: Used in the manufacture of final drug substances for diagnostic imaging, including iopromide, iohexol, and ioversol analogs.
• Research & Development: Serves as a critical reference standard and starting material in radiopharmaceutical and diagnostic agent R&D.
• Specialty Chemical Synthesis: Intermediate for creating other complex, triiodinated aromatic compounds with specific biological activity.

Basic Information

Product Name	N1,N3-Bis(1,3-Dihydroxypropan-2-Yl)-5-(2-Hydroxypropanamido)-2,4,6-Triiodoisophthalamide
CAS No.	62883-00-5
Molecular Formula	C17H23I3N3O8
Molecular Weight	835.09 g/mol
Synonyms	5-Acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; Iopromide Intermediate; Iohexol Related Compound; 5-(2-Hydroxypropanamido)-N1,N3-bis(1,3-dihydroxypropan-2-yl)-2,4,6-triiodobenzene-1,3-dicarboxamide; 2,4,6-Triiodo-5-lactamido-isophthalamic Acid Derivative; Non-Ionic Contrast Media Intermediate; Triiodoisophthalamide Derivative
EINECS	Contact for details

Quality Control

Our production of this high-value pharmaceutical intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines. Every batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, residual solvent analysis (GC), and elemental analysis for iodine content. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support audits and can provide DMF (Drug Master File) references as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Iodine Content	45.5% - 46.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.