Description

Amrinone Related Compound A (5-Carboxamide[3,4'-Bipyridin]-6(1H)-One) is a high-purity chemical reference standard essential for pharmaceutical research and development. This compound serves as a critical impurity marker and analytical standard for ensuring the quality and safety of the cardiotonic drug Amrinone (Inamrinone). It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in method development, stability studies, and regulatory compliance testing.

Application

• Pharmaceutical Impurity Profiling and Control: Used as a certified reference material (CRM) for the identification and quantification of related substances in Amrinone active pharmaceutical ingredient (API) and finished dosage forms.
• Analytical Method Development and Validation: Serves as a critical standard for developing and validating HPLC, UPLC, or LC-MS methods in quality control laboratories.
• Stability Indicating Studies: Employed to monitor degradation pathways and establish shelf-life specifications for Amrinone-based drug products.
• Regulatory Compliance and Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) to demonstrate thorough impurity characterization as per ICH guidelines.
• Pharmacological and Metabolic Research: Acts as a chemical intermediate or reference compound in studies investigating the metabolism and structure-activity relationships (SAR) of bipyridine derivatives.
• Quality Assurance/Quality Control (QA/QC): Integral for in-house quality testing, batch release, and supplier qualification processes to ensure API purity.

Basic Information

Item	Details
Product Name	Amrinone Related Compound A (100 Mg)
CAS No.	62749-46-6
Molecular Formula	C11H8N4O2
Molecular Weight	228.21 g/mol
Synonyms	5-Carboxamide[3,4'-Bipyridin]-6(1H)-One; 6(1H)-Pyridinone, 3,4'-bipyridine-5-carboxamide; Amrinone Impurity A; Inamrinone Related Compound A; 3,4'-Bipyridine-5-carboxamide, 6(1H)-one; 5-Carbamoyl-3,4'-bipyridin-6(1H)-one; Amrinone EP Impurity A
EINECS	Contact for details

Quality Control

Every batch of Amrinone Related Compound A is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use as a reference standard. A detailed Certificate of Analysis (COA) is supplied with each unit, reporting identity, purity (typically ≥95% by HPLC), and impurity profile. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and regulatory compliance.

Storage

Preserve in the original tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0% w/w
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.