Description

Rac 4-Hydroxydebrisoquine Hemisulfate is a key chemical intermediate and reference standard of significant importance in pharmaceutical research and development. This compound matters for its critical role in the study of drug metabolism, particularly in the investigation of cytochrome P450 2D6 (CYP2D6) enzyme activity and pharmacogenetics. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in metabolic studies, analytical method development, and the synthesis of more complex bioactive molecules.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method validation, quality control, and regulatory submissions in drug development.
• Metabolic Research: Serves as a crucial substrate or metabolite analog in studies investigating the CYP2D6 enzymatic pathway, a major system for drug metabolism.
• Pharmacogenetic Studies: Employed in clinical and preclinical research to understand individual variations in drug response and metabolism rates.
• Analytical Chemistry: Acts as a standard for calibrating equipment like HPLC, LC-MS, or GC-MS in bioanalytical laboratories.
• Chemical Synthesis: Functions as a building block or intermediate for the synthesis of more complex chemical entities or deuterated analogs for use as internal standards.
• Enzyme Kinetics: Utilized in vitro assays to determine enzyme inhibition or activity for drug-drug interaction studies.

Basic Information

Product Name	Rac 4-Hydroxydebrisoquine Hemisulfate
CAS No.	62580-84-1
Molecular Formula	C16H24N4O · ½H2SO4
Molecular Weight	Contact for details
Synonyms	4-Hydroxydebrisoquine Hemisulfate (racemic); Debrisoquine 4-ol Hemisulfate; (±)-4-Hydroxydebrisoquine Hemisulfate; 3,4-Dihydro-2(1H)-isoquinolinecarboximidamide, 4-hydroxy-1,2,3,4-tetrahydro-, hemisulfate, rac-; 4-OH-Debrisoquine Hemisulfate; 4-Hydroxydebrisoquine Hydrogen Sulfate; rac-4-Hydroxydebrisoquine Sulfate (1:0.5)
EINECS	Contact for details

Quality Control

Our Rac 4-Hydroxydebrisoquine Hemisulfate is produced and handled under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (e.g., HPLC purity) are provided to guarantee traceability and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.