Description

Mianserin n-Oxide CAS NO 62510-46-7 is a significant pharmaceutical intermediate and metabolite of the antidepressant drug Mianserin. This compound is crucial for research and development in neuropharmacology, serving as a key reference standard for analytical studies and metabolic pathway investigations. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and academic institutions focused on psychotropic drug metabolism and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of Mianserin and its related substances in drug substances and products.
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and bioavailability of the antidepressant Mianserin.
• Impurity Profiling: Serves as a known impurity standard for method development and validation in HPLC, LC-MS, and other chromatographic techniques to ensure drug purity and safety.
• Pharmacological Studies: Employed in preclinical research to understand the activity, toxicity, and degradation products of Mianserin.
• Quality Control Laboratories: Critical for compliance testing in pharmaceutical manufacturing to meet regulatory requirements (e.g., ICH Q3A/B) for impurity identification and control.
• Academic Research: Used in university and institutional research projects focused on organic synthesis, medicinal chemistry, and neuropharmacology.

Basic Information

Product Name	Mianserin n-Oxide
CAS No.	62510-46-7
Molecular Formula	C18H20N2O
Molecular Weight	280.37 g/mol
Synonyms	1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine N-Oxide; Mianserin N-Oxide; Mianserin Oxide; 6H-Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, 6-oxide; Mianserin Impurity C (Oxide); Norzepine N-Oxide; Tolvon N-Oxide
EINECS	Contact for details

Quality Control

Our Mianserin n-Oxide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and consistency. Quality is assured through comprehensive methods including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with each batch to support your research and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.