Description

Didesmethyl Citalopram-D4 is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analyses in pharmaceutical research and development. It is primarily utilized by analytical laboratories, CROs, and pharmaceutical manufacturers engaged in method development, pharmacokinetic studies, and quality control for citalopram and its metabolites.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the precise quantification of citalopram and its metabolites in biological matrices.
• Pharmaceutical R&D: Supports method development and validation in pharmacokinetic, bioequivalence, and metabolism studies.
• Forensic Toxicology: Enables accurate measurement of citalopram levels in forensic and clinical toxicology analyses.
• Reference Standard: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity.
• Metabolite Profiling: Aids in the identification and quantification of specific metabolic pathways in drug metabolism studies.
• Quality Control (QC) Testing: Employed in the QC laboratories of API manufacturers to monitor process-related impurities and degradation products.

Basic Information

Product Name	Didesmethyl Citalopram-D4
CAS No.	62498-69-5
Molecular Formula	C18H14D4FN2O
Molecular Weight	301.36 g/mol
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-(D4)isobenzofuran-1-carbonitrile; 1,3-Dihydro-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-5-(D4)isobenzofuran-1-carbonitrile; Didesmethyl Citalopram d4; Citalopram Impurity D4; Citalopram Didesmethyl D4; Deuterated Didesmethyl Citalopram; Lu 10-348-D4
EINECS	Contact for details

Quality Control

Our Didesmethyl Citalopram-D4 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm chemical and isotopic identity, purity, and absence of unlabeled species. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.