Description

n-Desmethyl Citalopram-D4 Oxalate is a high-purity, deuterium-labeled internal standard critical for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in sophisticated bioanalytical and pharmacokinetic studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units for method development and validation in mass spectrometry.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the accurate LC-MS/MS quantification of citalopram and its metabolites in biological matrices (plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug metabolism and clearance rates in clinical and preclinical research.
• Forensic and Clinical Toxicology: Used in confirmatory testing and high-accuracy measurements for therapeutic drug monitoring (TDM) and substance abuse panels.
• Drug Metabolism and Disposition Research: Facilitates studies on the metabolic pathways of citalopram, specifically investigating N-demethylation.
• Method Development and Validation: A key reference material for developing, optimizing, and validating robust analytical methods in compliance with GLP and FDA guidelines.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and stability testing of active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	n-Desmethyl Citalopram-D4 Oxalate
CAS No.	62498-68-4
Molecular Formula	C20H17D4F N2O • C2H2O4
Molecular Weight	407.43 g/mol
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile-D4 Oxalate; Desmethylcitalopram-D4 Oxalate; Didesmethylcitalopram-D4 Oxalate; Lu 10-005-D4 Oxalate; N-Desmethylcitalopram-D4 Oxalate; (RS)-1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile-D4 Oxalate
EINECS	Contact for details

Quality Control

Our n-Desmethyl Citalopram-D4 Oxalate is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical reference standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (HPLC), isotopic purity (D-content), and related substances. We adhere to relevant industry standards for reference materials to support your compliance with GLP and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be stored away from light. Keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.