Description

Bdellin CAS NO 62494-89-7 is a naturally occurring, low-molecular-weight proteinase inhibitor derived from leeches. This compound is valued for its potent and specific inhibitory activity against trypsin, plasmin, and other serine proteases, making it a critical research tool in biochemistry and pharmacology. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers for studying proteolytic pathways, developing anti-inflammatory agents, and creating assay controls.

Application

• Biochemical Research: Used as a specific inhibitor to study the kinetics and mechanisms of serine proteases like trypsin, plasmin, and kallikrein in vitro.
• Pharmaceutical Development: Serves as a reference standard and lead compound in the research of anti-inflammatory, anti-thrombotic, and anti-metastatic drug candidates.
• Diagnostic Reagents: Incorporated into diagnostic kits and assays to control or inhibit specific proteolytic activity, ensuring test accuracy and reliability.
• Cell Culture & Tissue Engineering: Applied in cell-based assays to modulate protease activity, helping to study cell migration, invasion, and extracellular matrix remodeling.
• Enzyme Purification: Utilized in affinity chromatography columns for the purification of specific serine proteases from complex biological mixtures.

Basic Information

Product Name	Bdellin
CAS No.	62494-89-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Bdellin; Bdellin B; Hirudo medicinalis trypsin inhibitor; Leech-derived trypsin-plasmin inhibitor; Bdellin inhibitor; Serine protease inhibitor from leech; Bdellin proteinase inhibitor
EINECS	Contact for details

Quality Control

Our Bdellin is produced and tested under strict quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot is characterized for its inhibitory potency and purity profile. A comprehensive Certificate of Analysis (COA), detailing specifications such as activity (IU/mg), purity (HPLC), and identity (IR), is provided to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to moisture, heat, or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Biological Activity	≥ 5000 IU/mg (vs. Trypsin)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.