Description

Methyl [2R-(2α,6α,7β)]-3-Methyl-8-Oxo-7-Phenylacetamido-5-Thia-1-Azabicyclo[4.2.0]Oct-3-Ene-2-Carboxylate is a key chiral intermediate in the synthesis of advanced pharmaceutical compounds, particularly β-lactam antibiotics. Its precise stereochemistry is critical for ensuring the biological activity and efficacy of the final active pharmaceutical ingredient (API). This high-purity intermediate is essential for research institutions and manufacturers engaged in the development and production of novel cephalosporin-class antibiotics and other specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of advanced cephalosporin antibiotics.
• API Synthesis: Used in research and commercial-scale production of active pharmaceutical ingredients (APIs) targeting bacterial infections.
• Organic Synthesis Research: A valuable chiral synthon for constructing complex β-lactam structures in medicinal chemistry.
• Process Development: Serves as a reference standard and starting material for optimizing synthetic routes in fine chemical manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	Methyl [2R-(2α,6α,7β)]-3-Methyl-8-Oxo-7-Phenylacetamido-5-Thia-1-Azabicyclo[4.2.0]Oct-3-Ene-2-Carboxylate
CAS No.	62284-26-8
Molecular Formula	C19H20N2O4S
Molecular Weight	372.44 g/mol
Synonyms	(6R,7R)-7-Phenylacetamido-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid methyl ester; Methyl (6R,7R)-7-(2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 7-ADCA Phenylglycyl Methyl Ester Derivative; Cephalosporin C-7 Side Chain Intermediate; 3-Methylcephem Ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is analyzed using advanced techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We support development under cGMP guidelines for applications requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.