Description

4-Bromo-Pyridine-2-Carbonitrile is a versatile and high-value brominated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a bromine substituent and a nitrile group on the pyridine ring, makes it an indispensable precursor for constructing complex heterocyclic systems and active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new molecular entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its pyridine core for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials and organic semiconductors.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form new carbon-carbon bonds.
• Nitrile Functionalization: The cyano group can be further transformed into amides, acids, or reduced to amines, expanding its utility in multi-step syntheses.

Basic Information

Product Name	4-Bromo-Pyridine-2-Carbonitrile
CAS No.	62150-45-2
Molecular Formula	C6H3BrN2
Molecular Weight	183.01 g/mol
Synonyms	4-Bromopyridine-2-carbonitrile; 2-Cyano-4-bromopyridine; 4-Bromo-2-cyanopyridine; 4-Bromopicolinonitrile; 2-Pyridinecarbonitrile, 4-bromo-; 4-Bromo-2-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-Pyridine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be kept under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.