Description

Boc-4-Iodo-L-Phenylalanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis and medicinal chemistry research. Its core value lies in providing a chemically orthogonal handle for site-specific modifications, enabling the creation of complex biomolecules and targeted drug candidates. This high-purity building block is critically needed by pharmaceutical R&D teams, peptide manufacturers, and academic laboratories developing novel therapeutics, diagnostic agents, and biochemical probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of peptide-based drugs and novel chemical entities targeting various diseases.
• Peptide Synthesis: Used in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methods to incorporate iodinated phenylalanine residues into peptide sequences.
• Bioconjugation & Radiolabeling: The iodine atom serves as a precursor site for radioiodination (e.g., with I-125 or I-131) to create tracers for imaging (SPECT) or targeted radiotherapy.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship studies by introducing a heavy halogen atom to modulate peptide conformation, binding affinity, and metabolic stability.
• Chemical Biology Probes: Facilitates the development of activity-based probes and affinity labels for studying enzyme function and protein-protein interactions.
• Cross-Coupling Reactions: The aryl iodide moiety is a versatile substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse functionalities.

Basic Information

Product Name	Boc-4-Iodo-L-Phenylalanine
CAS No.	62129-44-6
Molecular Formula	C₁₄H₁₈INO₄
Molecular Weight	391.20 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-4-iodo-L-phenylalanine; Boc-4-Iodo-L-Phe-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(4-iodophenyl)propanoic acid; tert-Butyloxycarbonyl-4-iodo-L-phenylalanine; N-Boc-4-iodo-L-phenylalanine; Boc-L-4-Iodophenylalanine; 4-Iodo-L-phenylalanine, N-Boc-protected; Boc-Phe(4-I)-OH
EINECS	Contact for details

Quality Control

Our Boc-4-Iodo-L-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-process controls and final release testing protocols to meet the exacting standards of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.