Description

2,5-Difluorobenzenesulfonyl Fluoride is a versatile and highly reactive organofluorine building block, primarily valued for its role as a key sulfonylating agent in advanced synthesis. Its significance lies in its ability to introduce the sulfonyl fluoride functional group, a crucial intermediate in the development of pharmaceuticals, agrochemicals, and specialty materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for complex chemical transformations.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs and protease inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its fluorine and sulfonyl fluoride moieties for enhanced bioactivity.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent inhibitors, exploiting the specific reactivity of the sulfonyl fluoride group.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and advanced materials where fluorinated aromatic units impart desirable thermal and chemical stability.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex, multi-substituted arene structures.
• Sulfonylation Agent: Used to introduce the benzenesulfonyl group into various nucleophiles, such as amines and alcohols, to create sulfonamides and sulfonate esters.

Basic Information

Product Name	2,5-Difluorobenzenesulfonyl Fluoride
CAS No.	62094-86-4
Molecular Formula	C6H3F3O2S
Molecular Weight	196.15 g/mol
Synonyms	1,4-Difluoro-2-sulfonylfluorobenzene; 2,5-Difluorophenylsulfonyl Fluoride; Benzenesulfonyl fluoride, 2,5-difluoro-; 2,5-Difluorobenzene-1-sulfonyl Fluoride; 2,5-DFBSF; 2,5-Difluorobenzenesulfonic Acid Fluoride
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzenesulfonyl Fluoride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain stability. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.