Description

Z-Arg-Amc CAS NO 62037-44-9 is a specialized fluorogenic peptide substrate designed for the sensitive detection and quantification of trypsin-like protease activity. This compound is critical for researchers and quality control laboratories requiring precise enzymatic assays. It is primarily utilized in biochemical research, pharmaceutical development, and diagnostic applications where monitoring protease function is essential.

Application

• Biochemical Research: As a selective substrate for trypsin, urokinase, and other serine proteases in enzyme kinetics and inhibition studies.
• Pharmaceutical Screening: High-throughput screening (HTS) of potential protease inhibitor drug candidates in drug discovery pipelines.
• Diagnostic Assays: Used in fluorometric assays for detecting and measuring protease activity in clinical and research samples.
• Cell Biology Studies: Investigating protease-mediated signaling pathways and cellular processes.
• Quality Control: Testing the activity and stability of enzyme preparations in biomanufacturing.
• Proteomics: A tool for characterizing protease specificity and function in complex biological systems.

Basic Information

Product Name	Z-Arg-Amc
CAS No.	62037-44-9
Molecular Formula	C₂₀H₂₉N₇O₅
Molecular Weight	447.49 g/mol
Synonyms	Benzyloxycarbonyl-L-arginine 7-amido-4-methylcoumarin; Z-Arg-AMC; Z-Arg-7-amido-4-methylcoumarin; Cbz-Arg-AMC; Nα-Carbobenzoxy-L-arginine 7-amido-4-methylcoumarin; Protease Substrate Z-Arg-AMC; Fluorogenic substrate for trypsin; L-Arginine, N2-[(phenylmethoxy)carbonyl]-, 1-(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-yl) ester
EINECS	Contact for details

Quality Control

Our Z-Arg-Amc is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. We provide Certificates of Analysis (COA) with detailed specifications for traceability and compliance, supporting research and GLP/GMP environments where data integrity is paramount.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Fluorogenic Activity	Functional activity confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.