Description

n-Cbz-(2R,3R)-3-Amino-2-Hydroxy-4-Phenylbutyric Acid is a high-purity, chiral amino acid derivative featuring a carboxybenzyl (Cbz) protecting group on the amine functionality. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceutical agents, particularly protease inhibitors. It is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for asymmetric synthesis and peptide mimetic development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of HIV protease inhibitors and other antiviral medications.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid building block to introduce specific stereochemistry.
• Asymmetric Synthesis: Employed as a starting material or intermediate for constructing complex molecules with defined stereocenters in medicinal chemistry programs.
• Bioconjugation & Labeling: The reactive carboxylic acid and protected amine groups allow for selective conjugation in the development of targeted drug delivery systems or biochemical probes.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, quality control, and regulatory submissions in API manufacturing.
• Academic & Industrial R&D: Utilized in research laboratories for exploring new synthetic methodologies and developing novel bioactive compounds.

Basic Information

Product Name	n-Cbz-(2R,3R)-3-Amino-2-Hydroxy-4-Phenylbutyric Acid
CAS No.	62023-58-9
Molecular Formula	C18H19NO5
Molecular Weight	329.35 g/mol
Synonyms	(2R,3R)-3-[[(Benzyloxy)carbonyl]amino]-2-hydroxy-4-phenylbutanoic Acid; (2R,3R)-3-[(Benzyloxycarbonyl)amino]-2-hydroxy-4-phenylbutyric Acid; (2R,3R)-N-Cbz-3-Amino-2-hydroxy-4-phenylbutyric Acid; (2R,3R)-AHPA-Cbz; Cbz-(2R,3R)-AHPA; (2R,3R)-3-(N-Cbz-Amino)-2-hydroxy-4-phenylbutyric Acid; (2R,3R)-N-Cbz-AHPA; Benzyl (2R,3R)-3-amino-2-hydroxy-4-phenylbutylcarbamate (carboxylic acid form)
EINECS	Contact for details

Quality Control

Our n-Cbz-(2R,3R)-3-Amino-2-Hydroxy-4-Phenylbutyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every lot to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (2R,3R) isomer
Specific Rotation	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.