Description

6-Oxycodol (Crm) is a key pharmaceutical intermediate and reference standard with the CAS registry number 61949-73-3. This compound is of significant importance in the research, development, and quality control of active pharmaceutical ingredients (APIs), particularly within the opioid analgesic class. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in synthesis, impurity profiling, and method validation. Our supply ensures high purity and batch-to-batch consistency critical for these demanding applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of complex active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control testing (e.g., HPLC, GC) in pharmaceutical analysis.
• Impurity Profiling: Serves as a certified reference material for identifying and quantifying related substances in drug substances and products.
• Pharmacological Research: Employed in preclinical and clinical studies to understand metabolic pathways and pharmacokinetics.
• Regulatory Compliance: Essential for generating data to meet the requirements of regulatory bodies like the FDA, EMA, and ICH guidelines.
• Custom Synthesis: A starting material for the preparation of novel derivatives and analogs in medicinal chemistry.

Basic Information

Product Name	6-Oxycodol (Crm)
CAS No.	61949-73-3
Molecular Formula	C18H21NO4
Molecular Weight	315.36 g/mol
Synonyms	14-Hydroxydihydrocodeinone; 14-Hydroxydihydrocodeinone; Dihydro-14-hydroxycodeinone; 6-Oxycodol; 4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one; Noroxycodone Impurity; Oxycodone Related Compound
EINECS	Contact for details

Quality Control

Every batch of our 6-Oxycodol (Crm) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use as a reference material, including identity confirmation, purity assay, and detailed impurity profiling. A Certificate of Analysis (COA) is supplied with each shipment, detailing results from advanced analytical techniques such as HPLC, GC, NMR, and MS. Our quality commitment aligns with ICH Q7 guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.