Description

(R,S)-4-Hydroxy Cyclophosphamide is a key intermediate metabolite of the alkylating agent cyclophosphamide. This compound matters significantly for pharmaceutical research and development, particularly in the study of drug metabolism, mechanism of action, and toxicity profiles. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in oncology research and the development of analytical reference standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and method validation in drug development and manufacturing.
• Metabolite Research: Critical for studying the metabolic activation pathway, pharmacokinetics, and pharmacodynamics of cyclophosphamide.
• Biochemical Assay Development: Employed in the development and calibration of analytical methods such as HPLC, LC-MS/MS, and immunoassays for metabolite detection.
• Toxicology Studies: Utilized to investigate the mechanisms of toxicity and side effects associated with cyclophosphamide therapy.
• Academic Research: Serves as a vital reagent in university and institutional labs for fundamental cancer research and chemotherapy studies.

Basic Information

Product Name	(R,S)-4-Hydroxy Cyclophosphamide
CAS No.	61903-30-8
Molecular Formula	C7H15Cl2N2O3P
Molecular Weight	277.09 g/mol
Synonyms	4-Hydroxycyclophosphamide; 4-Hydroxy Cyclophosphamide; 4-OH-CPA; NSC-26271; Aldophosphamide; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 4-oxide; Cyclophosphamide Monohydrate (4-hydroxy metabolite); 4-Hydroxy Cyclophosphamide (racemic)
EINECS	Contact for details

Quality Control

Our (R,S)-4-Hydroxy Cyclophosphamide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.