Description

Thymidylyl(3'->5')-2'-Deoxyadenosine Ammonium Salt is a high-purity dinucleoside monophosphate, a crucial building block in oligonucleotide synthesis. This compound is essential for researchers and manufacturers requiring precise, sequence-defined nucleic acid components for advanced applications. It is primarily utilized in the pharmaceutical, biotechnology, and life sciences research sectors for developing novel therapeutics, diagnostic probes, and molecular biology tools.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of DNA and RNA sequences.
• Antisense & siRNA Therapeutics: Used in the research and production of gene-silencing drugs and therapeutic oligonucleotides.
• PCR Primer & Probe Development: Serves as a critical component in manufacturing high-fidelity primers and fluorescent probes for diagnostic assays.
• Structural Biology Studies: Employed in crystallography and NMR studies to understand nucleic acid structure and protein-nucleic acid interactions.
• Bioconjugation & Labeling: Acts as a starting material for creating labeled nucleotides for imaging and detection applications.
• Standards & Reference Materials: Provides a certified reference standard for quality control in molecular biology and genetic testing.

Basic Information

Product Name	Thymidylyl(3'->5')-2'-Deoxyadenosine Ammonium Salt
CAS No.	61845-39-4
Molecular Formula	C20H28N7O12P • xNH3
Molecular Weight	Contact for details
Synonyms	d(TpA) Ammonium Salt; TpdA Ammonium Salt; Thymidylyl-(3′→5′)-2′-deoxyadenosine ammonium salt; 2′-Deoxyadenylyl-(5′→3′)-thymidine ammonium salt; dTpdA ammonium salt; T-A Dinucleotide Ammonium Salt; DNA Dinucleotide TpA; Adenosine, 2'-deoxy-, 5'-(trihydrogen diphosphate), 5'-5'-ester with thymidine, ammonium salt
EINECS	Contact for details

Quality Control

Our Thymidylyl(3'->5')-2'-Deoxyadenosine Ammonium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for critical research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant pharmacopeial standards and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Ammonium Content	Contact for details
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.