Description

Dechloro Anagrelide is a key pharmaceutical intermediate and reference standard of significant importance in modern drug development and manufacturing. This compound is primarily utilized in the synthesis and quality control of Anagrelide, a critical medication used for the treatment of essential thrombocythemia. It serves as an indispensable building block for pharmaceutical companies, research institutions, and analytical laboratories focused on hematological disorders and API production.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of the active pharmaceutical ingredient (API) Anagrelide Hydrochloride.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control testing of Anagrelide and related products.
• Impurity Standard: Employed in the identification and quantification of process-related impurities and degradation products during API manufacturing and stability studies.
• Research & Development: Serves as a vital tool in pharmacological and metabolic studies to understand the structure-activity relationship of Anagrelide analogs.
• Regulatory Compliance: Essential for generating data to meet regulatory submission requirements (e.g., ICH guidelines) for drug master files (DMFs).

Basic Information

Product Name	Dechloro Anagrelide
CAS No.	61834-95-5
Molecular Formula	C10H7N3O
Molecular Weight	185.18 g/mol
Synonyms	6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one; 1,5-Dihydroimidazo[2,1-b]quinazolin-2(3H)-one, 6,7-dichloro-; Anagrelide Impurity D; Anagrelide Related Compound D; Dechlorinated Anagrelide; 6,7-Dichloro-3,4-dihydroimidazo[2,1-b]quinazolin-2(1H)-one; UK-57269-26
EINECS	Contact for details

Quality Control

Our Dechloro Anagrelide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications aligned with ICH Q3A/B guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.