Description

L-1-Cbz-Pipecolinamide is a protected pipecolinamide derivative, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex molecules, particularly in the development of novel pharmaceuticals and bioactive compounds. This high-purity intermediate is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Peptidomimetic Synthesis: Used in the construction of peptide analogs and mimetics where the pipecolinic acid scaffold is required for conformational constraint and biological activity modulation.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective synthesis routes to introduce defined stereocenters.
• Agrochemical Research: Serves as a building block for novel crop protection agents and herbicides requiring specific stereochemistry.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	L-1-Cbz-Pipecolinamide
CAS No.	61703-39-7
Molecular Formula	C14H18N2O3
Molecular Weight	262.31 g/mol
Synonyms	(S)-1-[(Benzyloxy)carbonyl]piperidine-2-carboxamide; (S)-1-Cbz-Pipecolinamide; (S)-N-[(Benzyloxy)carbonyl]pipecolic acid amide; L-1-Carbobenzyloxypipecolinamide; (2S)-1-[(Phenylmethoxy)carbonyl]piperidine-2-carboxamide; (S)-1-Cbz-2-piperidinecarboxamide; 1-Cbz-L-Pipecolinamide; L-Pipecolinic acid-1-Cbz amide
EINECS	Contact for details

Quality Control

Our L-1-Cbz-Pipecolinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.