Description

Cefotiam CAS NO 61622-34-2 is a second-generation cephalosporin antibiotic belonging to the cephem class, valued for its broad-spectrum activity against both gram-positive and gram-negative bacteria. Its primary commercial importance lies in its use as a key pharmaceutical intermediate and reference standard in the research, development, and quality control of antibiotic formulations. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical, biotechnology, and analytical chemistry sectors who require high-purity materials for synthesis and analysis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of finished antibiotic drug products and novel cephalosporin derivatives.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method validation, quality control (QC), and regulatory compliance testing of antibiotic products.
• Research & Development: Employed in microbiological and pharmacological studies to investigate antibacterial mechanisms, resistance patterns, and efficacy.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the production of injectable and other dosage forms of cefotiam-based antibiotics.
• Veterinary Medicine: Applied in the development of antibacterial treatments for animal health.

Basic Information

Product Name	Cefotiam
CAS No.	61622-34-2
Molecular Formula	C18H23N9O4S3
Molecular Weight	525.63 g/mol
Synonyms	Cefotiam; CGP-14221/E; Halospor; Pansporin; (6R,7R)-7-[[(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefotiamum; Cefotiam Base
EINECS	262-857-9

Quality Control

Our Cefotiam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical R&D and intermediate use. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles upon request, supporting compliance with cGMP and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.