Description

(6R-Trans)-7-Amino-3-[[[1-[2-(Dimethylamino)Ethyl]-1H-Tetrazol-5-Yl]Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate, representing a critical building block in modern antibiotic synthesis. Its value lies in its role as a key precursor for the production of potent third-generation cephalosporin antibiotics, enabling the development of effective treatments against resistant bacterial strains. This compound is essential for pharmaceutical manufacturers and research institutions focused on active pharmaceutical ingredient (API) development, antibiotic research, and the synthesis of novel β-lactam therapeutics.

Application

• Primary Intermediate for Cephalosporin Antibiotics: Serves as a crucial precursor in the synthesis of advanced cephalosporin drugs, particularly those with enhanced gram-negative activity.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the final chemical steps for producing bulk antibiotic APIs under current Good Manufacturing Practices (cGMP).
• Pharmaceutical Research & Development: A key starting material for medicinal chemists developing new β-lactam antibiotic analogs and combating antibiotic resistance.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale production runs for new antibiotic formulations.
• Reference Standard: High-purity grades are used as analytical reference standards for quality control and regulatory submissions.

Basic Information

Product Name	(6R-Trans)-7-Amino-3-[[[1-[2-(Dimethylamino)Ethyl]-1H-Tetrazol-5-Yl]Thio]Methyl]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	61607-66-7
Molecular Formula	C14H20N8O3S2
Molecular Weight	412.49 g/mol
Synonyms	7-Amino-3-[(1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cephalosporin C-7 Nucleus Derivative; 7-ACA Tetrazole Derivative; (6R,7R)-7-Amino-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-AT; Antibiotic Intermediate 61607-66-7.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent pharmaceutical-grade quality standards. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability for critical API synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents. We support compliance with cGMP guidelines and relevant pharmacopeial standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.