Description

(2S,4S)-(-)-n-Boc-4-Diphenylphosphino-2-Diphenylphosphinomethyl-Pyrrolidine CAS NO 61478-28-2 is a high-value, chiral bidentate phosphine ligand of the P,N-type, widely recognized for its pivotal role in asymmetric catalysis. Its significance lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in hydrogenation, hydroformylation, and cross-coupling reactions.

Application

• As a privileged ligand for asymmetric hydrogenation of olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Catalyst component in enantioselective hydroformylation reactions to produce chiral aldehydes.
• Ligand for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) requiring chiral induction.
• Use in asymmetric allylic alkylation and other C-C bond-forming processes.
• Key chiral auxiliary in the development of novel catalytic systems for academic and industrial research.
• Production of high-value agrochemicals and flavor & fragrance compounds where enantiopurity is mandated.

Basic Information

Product Name	(2S,4S)-(-)-n-Boc-4-Diphenylphosphino-2-Diphenylphosphinomethyl-Pyrrolidine
CAS No.	61478-28-2
Molecular Formula	C35H38NO2P2
Molecular Weight	590.63 g/mol
Synonyms	(2S,4S)-(-)-1-(tert-Butoxycarbonyl)-4-(diphenylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine; (S,S)-(-)-t-Bu-PHOX; (S,S)-t-Bu-PHOX Ligand; (2S,4S)-Boc-PHOX; (2S,4S)-tert-ButylPHOX; (S,S)-Boc-PHOX; Josiphos SL-J009-1 type ligand; Chiral P,N-Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure exceptional purity and enantiomeric excess, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, chiral purity (by HPLC or NMR), and impurity profiles. Our quality systems support development under cGMP guidelines for pharmaceutical applications, ensuring full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or ambient conditions should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.