Description

8-Hydroxy Amoxapine is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant amoxapine. This compound matters for its critical role in drug metabolism studies, analytical reference standard preparation, and the development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) and high-purity reference materials.

Application

• Primary reference standard for the quantitative and qualitative analysis of amoxapine and its metabolites in pharmaceutical formulations and biological matrices.
• Critical intermediate in the research-scale synthesis and process development of tricyclic antidepressant compounds.
• Essential metabolite used in pharmacokinetic and drug metabolism studies to understand the biotransformation pathways of amoxapine.
• Key component in the development and validation of analytical methods, including HPLC, LC-MS, and GC-MS, for impurity profiling.
• Building block for medicinal chemistry research aimed at developing new central nervous system (CNS) active molecules with improved efficacy and safety profiles.
• Used in stability studies and forced degradation studies to identify and characterize potential degradation products of amoxapine-based drug products.

Basic Information

Product Name	8-Hydroxy Amoxapine
CAS No.	61443-78-5
Molecular Formula	C₁₇H₁₆ClN₃O₂
Molecular Weight	329.78 g/mol
Synonyms	8-Hydroxyamoxapine; 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol; Amoxapine, 8-hydroxy-; 8-OH-Amoxapine; Loxapine metabolite 8-hydroxy; 8-Hydroxy Loxapine; 61443-78-5; 8-Hydroxy Amoxapine (Metabolite)
EINECS	Contact for details

Quality Control

Our 8-Hydroxy Amoxapine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical reference standards and advanced intermediates. Certificates of Analysis (COA) detailing HPLC purity, related substances, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.