Description

Desipramine-2,4,6,8-D4 Hcl is a deuterated analog of the tricyclic antidepressant desipramine, where four hydrogen atoms at the 2, 4, 6, and 8 positions of the aromatic rings are replaced with deuterium. This compound is a high-purity, stable isotope-labeled internal standard, essential for ensuring accuracy and reproducibility in quantitative analytical methods. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and bioanalytical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of desipramine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Metabolism Studies: Used in drug metabolism and pharmacokinetics (DMPK) research to track and quantify the parent drug, enabling detailed studies on absorption, distribution, metabolism, and excretion (ADME).
• Forensic and Clinical Toxicology: Provides high reliability in confirmatory testing for desipramine in forensic analysis and therapeutic drug monitoring (TDM) programs.
• Method Development and Validation: A key tool for developing, optimizing, and validating robust bioanalytical assays in compliance with regulatory guidelines (e.g., FDA, EMA).
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques to minimize matrix effects and improve measurement accuracy.
• Reference Material for Quality Control: Acts as a certified reference material (CRM) for calibrating equipment and verifying analytical results within quality control laboratories.

Basic Information

Product Name	Desipramine-2,4,6,8-D4 Hcl
CAS No.	61361-34-0
Molecular Formula	C18H18D4N2•HCl
Molecular Weight	307.86 g/mol (for free base C18H18D4N2>)
Synonyms	Desipramine-d4 Hydrochloride; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenzo[b,f]azepine-2,4,6,8-d4 Hydrochloride; Norimipramine-d4 HCl; Desmethylimipramine-d4 Hydrochloride; DMI-d4 HCl; NSC 114900-d4; Pertofrane-d4 (labeled analog); N-Desmethylimipramine-d4 HCl
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch of Desipramine-2,4,6,8-D4 Hcl is comprehensively characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (typically >98 atom % D), chemical purity, and analytical results. We support compliance with GMP/GLP principles for use in regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Keep the container tightly sealed after each use to prevent absorption of moisture from the atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.