Description

4-Fluoro-3-Nitroanisole is a versatile aromatic nitro compound and a key fluorinated building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for selective chemical transformations, making it indispensable for creating complex molecular architectures. This intermediate is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a key building block for developing advanced herbicides, fungicides, and insecticides, where the fluorine atom can improve biological activity and environmental profile.
• Liquid Crystal & OLED Material Research: Used in the development of fluorinated organic electronic materials, where its structure contributes to desired dielectric and luminescent properties.
• Dye & Pigment Manufacturing: Acts as an intermediate for synthesizing specialized fluorinated dyes and pigments with unique color fastness and spectral characteristics.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form complex biaryl structures.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in fluorination chemistry and nucleophilic aromatic substitution.

Basic Information

Product Name	4-Fluoro-3-Nitroanisole
CAS No.	61324-93-4
Molecular Formula	C7H6FNO3
Molecular Weight	171.13 g/mol
Synonyms	1-Fluoro-2-Methoxy-5-Nitrobenzene; 3-Nitro-4-Fluoroanisole; 4-Fluoro-3-Nitrophenyl Methyl Ether; 2-Methoxy-5-Nitrofluorobenzene; 5-Fluoro-2-Nitroanisole; Anisole, 4-fluoro-3-nitro-; Benzene, 1-fluoro-2-methoxy-5-nitro-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Nitroanisole is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.