Description

Boc-D-Arg(Tos)-Oh is a protected derivative of the D-enantiomer of the amino acid arginine, specifically designed for peptide synthesis. This compound is a critical building block in the pharmaceutical industry, enabling the controlled assembly of complex peptide sequences with high stereochemical purity. It is primarily utilized by research institutions and manufacturers engaged in the development of therapeutic peptides, peptidomimetics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of D-arginine in custom peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drug candidates, including antimicrobial and anticancer agents.
• Bioconjugation: Serves as a modified amino acid for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Biochemical Tool Development: Employed in the synthesis of enzyme substrates, inhibitors, and probes for studying biological pathways.
• Process Development & Scale-Up: Supports the transition from laboratory-scale research to commercial manufacturing of peptide APIs.

Basic Information

Product Name	Boc-D-Arg(Tos)-Oh
CAS No.	61315-61-5
Molecular Formula	C₁₈H₂₈N₄O₆S
Molecular Weight	428.50 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-ω-tosyl-D-arginine; Boc-D-Arg(Tos)-OH; (2R)-5-[(diaminomethylidene)amino]-2-[[(2-methylpropan-2-yl)oxycarbonyl]amino]-N-(4-methylphenyl)sulfonylpentanamide; tert-Butoxycarbonyl-D-arginine(Tosyl)-OH; Boc-D-Arg(Tos); D-Arg(Boc,Tos)-OH; N-Boc-N'-Tosyl-D-arginine
EINECS	Contact for details

Quality Control

Our Boc-D-Arg(Tos)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.