Description

Dehydro Loperamide is a key pharmaceutical intermediate and a derivative of the antidiarrheal agent loperamide. This compound is valued for its role in the synthesis and research of active pharmaceutical ingredients (APIs) targeting gastrointestinal disorders. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in drug development and production.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of loperamide hydrochloride and related antidiarrheal medications.
• Active Pharmaceutical Ingredient (API) Research: Serves as a reference standard and a building block in the development of new gastrointestinal therapeutics.
• Biochemical Research: Used in studies investigating opioid receptor activity and mechanisms of action in the gut.
• Quality Control & Analytical Standards: Employed as a high-purity standard in HPLC and other analytical methods for drug purity testing.
• Process Development: Integral to scaling up and optimizing manufacturing processes for loperamide-based drugs.

Basic Information

Product Name	Dehydro Loperamide
CAS No.	61299-42-1
Molecular Formula	C₂₉H₃₃ClN₂O₂
Molecular Weight	477.04 g/mol
Synonyms	4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide; Deshydroxy Loperamide; Loperamide Impurity; Loperamide Related Compound; Loperamide Intermediate; 1-Piperidinebutyramide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-; Loperamide EP Impurity B
EINECS	Contact for details

Quality Control

Our Dehydro Loperamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.