Description

4-Chloro-2-Iodobenzonitrile is a versatile halogenated benzonitrile derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and iodo substituents, makes it a valuable precursor for constructing complex molecules via cross-coupling reactions and nucleophilic aromatic substitution. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, enabling the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its reactive halogen sites.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Sonogashira couplings to introduce the substituted phenyl moiety into more complex structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for methodology development and library synthesis.
• Ligand and Catalyst Preparation: Used to synthesize functionalized ligands for transition metal catalysis.

Basic Information

Product Name	4-Chloro-2-Iodobenzonitrile
CAS No.	61272-75-1
Molecular Formula	C7H3ClIN
Molecular Weight	263.46 g/mol
Synonyms	2-Iodo-4-chlorobenzonitrile; 4-Chloro-2-iodobenzonitrile; 2-Iodo-4-chlorobenzene carbonitrile; Benzonitrile, 4-chloro-2-iodo-; 4-Chloro-2-iodo-benzonitrile; 4-Chloro-2-iodobenznitrile; 4-Chloro-2-iodobenzyl cyanide (common misnomer)
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Iodobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.