Description

Capsaicin Impurity 3 is a high-purity chemical reference standard used for analytical and research purposes. This compound is critical for ensuring the quality, safety, and efficacy of capsaicin and related capsaicinoid products by serving as a known benchmark in chromatographic analysis. It is primarily required by pharmaceutical R&D laboratories, quality control (QC) departments, and analytical service providers involved in the development and testing of topical analgesics, dietary supplements, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Impurity Profiling and Identification: Used as a certified reference material (CRM) to identify, quantify, and monitor Capsaicin Impurity 3 in bulk capsaicin and finished pharmaceutical products.
• Analytical Method Development and Validation: Serves as a critical standard for developing, optimizing, and validating HPLC, UPLC, and GC methods in compliance with ICH guidelines.
• Quality Control and Assurance (QC/QA): Essential for routine batch testing to ensure capsaicin raw materials and formulations meet stringent purity specifications and regulatory standards.
• Stability Studies: Employed as a marker compound in forced degradation and shelf-life studies to track impurity formation over time.
• Regulatory Submissions: Provides necessary data for drug master files (DMFs), investigational new drug (IND) applications, and new drug applications (NDAs).
• Research and Development: Used in academic and industrial research to study the metabolism, synthesis pathways, and degradation products of capsaicinoids.

Basic Information

Product Name	Capsaicin Impurity 3
CAS No.	61229-06-9
Molecular Formula	C18H27NO3
Molecular Weight	305.41 g/mol
Synonyms	8-Methyl-N-vanillyl-trans-6-nonenamide; Dihydrocapsaicin Impurity; (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; Capsaicin Analog; Nonivamide Related Compound; trans-8-Methyl-N-vanillyl-6-nonenamide; Capsaicin EP Impurity C; A typical capsaicinoid impurity.
EINECS	Contact for details

Quality Control

Every batch of Capsaicin Impurity 3 is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and assay testing using validated methods such as HPLC, NMR, and mass spectrometry to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA), detailing batch-specific results, is provided with each shipment to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.