Description

2-Bromo-4-Fluorophenylacetonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce key functional groups into active ingredients.

Application

2-Bromo-4-Fluorophenylacetonitrile serves as a key synthetic precursor in several high-value industrial sectors. Its primary applications include:

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and as kinase inhibitors.
• Agrochemical Synthesis: Acts as a building block for developing novel herbicides, fungicides, and pesticides, leveraging the bioactivity of the fluorine and bromine motifs.
• Liquid Crystal & OLED Materials: Employed in the production of advanced electronic materials, where its aromatic core and halogen atoms contribute to desired electronic and morphological properties.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Cyanomethylation Agent: The nitrile group adjacent to the aromatic ring is useful for further functionalization and ring-forming reactions.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry in both academic and industrial R&D settings.

Basic Information

Product Name	2-Bromo-4-Fluorophenylacetonitrile
CAS No.	61150-58-1
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	(2-Bromo-4-fluorophenyl)acetonitrile; 2-Bromo-4-fluorobenzyl cyanide; α-Bromo-4-fluorophenylacetonitrile; 4-Fluoro-2-bromophenylacetonitrile; 2-Bromo-4-fluoro-α-cyanotoluene; (2-Bromo-4-fluorophenyl)ethanenitrile; 2-Bromo-4-fluorobenzeneacetonitrile
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as confirmed by HPLC, GC, NMR, and IR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. This compound is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.