Description

Preproinsulin is a single-chain polypeptide precursor protein that is the biosynthetic forerunner to the vital metabolic hormone insulin. This compound matters as a critical intermediate in the study of insulin biosynthesis, folding, and post-translational processing. It is primarily needed by researchers and manufacturers in the pharmaceutical and biotechnology sectors for use in biochemical research, diagnostic development, and as a reference standard in quality control for insulin production.

Application

• Biochemical Research: Fundamental studies on protein folding, prohormone conversion, and insulin biosynthesis pathways.
• Pharmaceutical Reference Standard: Used as a high-purity calibrant in the quality control and assay validation of recombinant insulin and insulin analog products.
• Diagnostic Development: Serves as a key antigen or standard in the development and calibration of immunoassays for diabetes research and clinical diagnostics.
• Enzymology Studies: Substrate for investigating the activity and specificity of prohormone convertase enzymes (PC1/3 and PC2).
• Cell Biology: Used in research focused on the secretory pathway and endoplasmic reticulum function in pancreatic beta cells.

Basic Information

Product Name	Preproinsulin
CAS No.	61116-24-3
Molecular Formula	C254H377N65O76S6
Molecular Weight	~9390.5 g/mol (Theoretical average)
Synonyms	Preproinsulin human; Insulin precursor; Proinsulin precursor; Human preproinsulin; INS gene product; Pre-pro-insulin; Insulin, prepro-; UniProt P01308 (precursor)
EINECS	Contact for details

Quality Control

Our Preproinsulin is produced and handled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, mass spectrometry, and amino acid analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and bioactivity is provided with each batch to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by in vitro conversion to insulin

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.