Description

L-Tryptophan, [5-3H]- is a high-specific-activity, tritium-labeled derivative of the essential amino acid L-Tryptophan. This radiolabeled compound is a critical tool for advanced biochemical and pharmacological research, enabling precise metabolic pathway tracing and receptor binding studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic developers in the fields of neuroscience, protein metabolism, and drug discovery.

Application

• Biochemical Tracer Studies: Used to investigate the metabolism, biosynthesis, and catabolism of tryptophan and related compounds like serotonin and melatonin.
• Neuropharmacology Research: Essential for autoradiography and binding assays to study serotonin synthesis, transport, and receptor interactions in the central nervous system.
• Protein and Peptide Labeling: Serves as a radiolabeled precursor for in vitro or in vivo protein synthesis studies and metabolic labeling experiments.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) and ADME (Absorption, Distribution, Metabolism, Excretion) studies for candidate drugs targeting tryptophan pathways.
• Diagnostic Agent Development: Acts as a key starting material for developing novel radioligands and probes for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging.
• Nutritional and Metabolic Research: Applied in studies examining amino acid uptake, protein turnover, and the role of tryptophan in health and disease states.

Basic Information

Product Name	L-Tryptophan, [5-3H]-
CAS No.	61049-01-2
Molecular Formula	C11H103H2N2O2 *
Molecular Weight	~207.2 g/mol (for unlabeled C11H12N2O2)
Synonyms	(S)-2-Amino-3-(5-3H-indol-3-yl)propanoic acid; L-α-Amino-1H-indole-3-propanoic acid-5-3H; Tritiated L-Tryptophan; [5-3H]-L-Tryptophan; 3H-L-Tryptophan; Tryptophan-5-3H; L-TRP-5-3H; Radioactive Tryptophan
EINECS	Contact for details

* Formula represents the structure with tritium (3H) at the 5-position of the indole ring. Exact molecular weight varies with specific activity.

Quality Control

Every batch of L-Tryptophan, [5-3H]- is manufactured and handled under strict quality protocols to ensure radiochemical purity and stability. Our products undergo rigorous analytical testing, including HPLC and radio-HPLC, to confirm identity, specific activity, and radiochemical purity. Certificates of Analysis (COA) detailing specific activity (Ci/mmol or GBq/mmol), concentration, solvent, and purity are provided with each shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store frozen (-20°C or below) in the original solvent as supplied. For long-term storage, maintain in a designated radioactive materials area at -70°C or below. Always follow local and national regulations for the safe handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC/Co-injection)	Conforms to reference standard
Radiochemical Purity (Radio-HPLC/TLC)	≥ 95% to 98%
Specific Activity	10 - 100 Ci/mmol (Typical range, custom available)
Chemical Purity (HPLC)	≥ 98%
Concentration	1 mCi/mL (Typical, in ethanol/water or specified solvent)
Solvent	Ethanol/Water (e.g., 2:98 v/v) or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.