Description

L-Alanine, n-[(1,1-Dimethylethoxy)Carbonyl]-3-[[(Phenylmethoxy)Carbonyl]Amino]-, Methyl Ester CAS NO 61040-22-0 is a protected amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a crucial building block for the controlled assembly of peptides and other complex biomolecules, offering precise stereochemical control. It is primarily sought after by pharmaceutical research and fine chemical industries for developing novel therapeutic agents and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential addition of amino acids, particularly where the side-chain of alanine requires orthogonal protection.
• Solution-Phase Peptide Synthesis: Used in the synthesis of short to medium-length peptide sequences for research and development purposes.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and peptidomimetics.
• Bioconjugation Chemistry: Employed in the design and synthesis of peptide-drug conjugates, antibody-drug conjugates (ADCs), and other targeted delivery systems.
• Proteomics and Biochemical Research: Used to create custom peptides for enzyme studies, receptor binding assays, and epitope mapping.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of peptide-like compounds for high-throughput screening.

Basic Information

Product Name	L-Alanine, n-[(1,1-Dimethylethoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-, methyl ester
CAS No.	61040-22-0
Molecular Formula	C17H24N2O6
Molecular Weight	352.38 g/mol
Synonyms	Boc-Ala(Z)-OMe; Boc-L-Ala(Z)-OMe; Methyl N-Boc-N-Cbz-L-alaninate; Nα-Boc-Nβ-Cbz-L-alanine methyl ester; (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((benzyloxycarbonyl)amino)propanoate; Boc-Ala(Cbz)-OMe; N-Boc-N'-Cbz-L-alanine methyl ester; Boc-Cbz-L-Ala-OMe
EINECS	Contact for details

Quality Control

Our Boc-Ala(Z)-OMe is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated research and development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-15° to -20° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.