Description

Ceforanide is a second-generation cephalosporin antibiotic belonging to the β-lactam class. Its primary value lies in its broad-spectrum bactericidal activity against a wide range of Gram-positive and Gram-negative pathogens. This makes it a critical intermediate in the synthesis of finished pharmaceutical dosage forms for treating serious infections. Industries involved in pharmaceutical manufacturing, particularly of injectable antibiotics, are the primary users of this high-purity active pharmaceutical ingredient.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of finished ceforanide-based antibiotic formulations.
• Injectable Antibiotic Production: Manufacture of sterile ceforanide for injection, used in clinical settings for systemic infections.
• Research & Development: Serving as a reference standard or starting material in antimicrobial research and new drug development projects.
• Veterinary Medicine: Potential application in the development of antibacterial treatments for veterinary use.
• Bulk Drug Substance: Supplied as an Active Pharmaceutical Ingredient (API) to formulation facilities for final drug product manufacturing.

Basic Information

Product Name	Ceforanide
CAS No.	60925-61-3
Molecular Formula	C20H18N8O6S2
Molecular Weight	530.53 g/mol
Synonyms	Ceforanide; BL-S 578; Ceforamide; Precef; Ceforanide (USAN); 7-[[(Aminocarbonyl)oxy]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, 7-[[2-(Aminomethyl)phenyl]acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-; (6R,7R)-7-[(2-(Aminomethyl)phenyl)acetamido]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 7-carbamoyloxymethyl ester
EINECS	262-637-6

Quality Control

Our Ceforanide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, residual solvents, and microbiological quality. We adhere to cGMP (Current Good Manufacturing Practice) guidelines to ensure consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can compromise stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.2%
Microbiological Enumeration	Total aerobic microbial count ≤ 1000 cfu/g Total combined yeasts/molds ≤ 100 cfu/g
Specific Optical Rotation	+55° to +65° (c=1, in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.