Description

(+/-)-N,n-Dimethyl-1-(2-Diphenylphosphino)Ferrocenylethylamine Monohydrate CAS NO 60816-98-0 is a chiral ferrocenyl phosphine ligand, a cornerstone in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in a wide range of transition metal-catalyzed reactions, enabling the production of optically pure compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance ligands for synthesizing chiral intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral amines, amino acids, and alcohols.
• Asymmetric Cross-Coupling Reactions: Used in C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, to create chiral biaryl and other complex molecular architectures.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer drug candidates and active pharmaceutical ingredients (APIs) with high optical purity.
• Agrochemical Development: Applied in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is often enantiomer-specific.
• Academic & Industrial R&D: Serves as a versatile tool for developing new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.
• Fine Chemical Manufacturing: Used in the custom synthesis of high-value, complex chiral molecules for various advanced material and specialty chemical applications.

Basic Information

Product Name	(+/-)-N,n-Dimethyl-1-(2-Diphenylphosphino)Ferrocenylethylamine Monohydrate
CAS No.	60816-98-0
Molecular Formula	C26H28FeNOP • H2O
Molecular Weight	461.32 g/mol (anhydrous basis)
Synonyms	Josiphos SL-J009-1; (R,S)-PPF-P(t-Bu)2; 1-[(R)-1-(Dimethylamino)ethyl]-2-(Diphenylphosphino)ferrocene; (R,S)-1-[(Dimethylamino)ethyl]-2-(Diphenylphosphino)ferrocene; (R,S)-N,N-Dimethyl-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethylamine; (±)-N,N-Dimethyl-1-[2-(Diphenylphosphino)ferrocenyl]ethylamine Monohydrate; (R,S)-PPF-P(t-Bu)2; Chiral Josiphos-type Ligand
EINECS	Contact for details

Quality Control

Our (+/-)-N,n-Dimethyl-1-(2-Diphenylphosphino)Ferrocenylethylamine Monohydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral analysis, to ensure identity, purity, and performance consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific research or cGMP requirements for advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	Racemic mixture (50:50 enantiomeric ratio)
Water Content (KF)	3.5 - 5.5% (corresponding to monohydrate)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.