Description

4-Bromo-1-Chloro-2-Fluorobenzene is a high-purity halogenated benzene derivative, a key building block in advanced organic synthesis. Its precise halogen substitution pattern makes it an indispensable intermediate for creating complex molecules with specific electronic and steric properties. This compound is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for constructing active pharmaceutical ingredients (APIs), crop protection agents, and specialty polymers.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in the development of active pharmaceutical ingredients (APIs) for central nervous system (CNS) and anti-inflammatory therapies.
• Agrochemical Synthesis: Used as a key building block for manufacturing advanced herbicides, fungicides, and insecticides, where the halogen atoms enable specific biological activity.
• Liquid Crystal & OLED Materials: Serves as a foundational unit in the production of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to their stability and electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the reactivity of the bromo and chloro substituents, allowing for sequential functionalization.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating complex aromatic scaffolds for various applications.
• Specialty Polymer Monomer: Acts as a monomer or co-monomer in the synthesis of high-performance, halogenated engineering plastics and resins with enhanced flame retardancy and chemical resistance.

Basic Information

Product Name	4-Bromo-1-Chloro-2-Fluorobenzene
CAS No.	60811-18-9
Molecular Formula	C6H3BrClF
Molecular Weight	209.44 g/mol
Synonyms	1-Bromo-4-Chloro-3-Fluorobenzene; 2-Fluoro-4-Bromochlorobenzene; 4-Bromo-2-Fluorochlorobenzene; 3-Fluoro-4-Chlorobromobenzene; 4-Chloro-2-fluorobromobenzene; Benzene, 1-bromo-4-chloro-2-fluoro-; (4-Bromo-2-fluorophenyl)chloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Chloro-2-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistent lot-to-lot performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.