Description

Desmethylnaproxen is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) naproxen. This compound is of significant value in analytical chemistry and pharmaceutical development for method validation, pharmacokinetic studies, and impurity profiling. It is primarily required by research institutions, analytical laboratories, and pharmaceutical manufacturers engaged in drug metabolism research, quality control, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of naproxen and its metabolites in biological matrices and pharmaceutical formulations.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research to understand the metabolic pathway and clearance of naproxen.
• Impurity Profiling: Serves as a known impurity standard in the HPLC/LC-MS analysis of naproxen active pharmaceutical ingredient (API) to ensure product purity and compliance with ICH guidelines.
• Analytical Method Development: A critical component for developing and validating robust bioanalytical methods in compliance with GLP and GMP standards.
• Clinical Research: Employed in clinical trials to monitor drug metabolism and establish correlation between plasma levels and therapeutic effect.
• Synthetic Intermediate: Used in the research-scale synthesis of novel naproxen analogs or prodrugs with potentially improved efficacy or safety profiles.

Basic Information

Product Name	Desmethylnaproxen
CAS No.	60756-73-2
Molecular Formula	C₁₃H₁₄O₃
Molecular Weight	218.25 g/mol
Synonyms	6-Desmethylnaproxen; 6-Demethylnaproxen; 2-(5-Hydroxy-6-methoxy-2-naphthyl)propanoic acid; Naproxen Impurity C; Naproxen Metabolite; O-Desmethylnaproxen; (+)-6-O-Desmethylnaproxen; U-28304
EINECS	Contact for details

Quality Control

Our Desmethylnaproxen is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets high-purity standards suitable for use as a reference material. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We support compliance with ICH Q3B guidelines for impurities and can supply material tailored to your specific pharmacopeial or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.