Description

Toxin Iii (Anemonia Sulcata) is a potent neurotoxic polypeptide isolated from the sea anemone *Anemonia sulcata*. This compound is of significant interest in neuroscience research and pharmaceutical development due to its specific and high-affinity interaction with voltage-gated sodium channels. It serves as a critical tool for researchers and developers in the life sciences sector, particularly those focused on ion channel physiology, neuropharmacology, and the discovery of novel therapeutic agents.

Application

• Neuroscience Research: As a selective probe for studying the structure, function, and modulation of voltage-gated sodium channels (NaV channels) in neuronal and muscular tissues.
• Pharmacological Tool: Used in high-throughput screening (HTS) assays and electrophysiology studies to identify and characterize new channel blockers or modulators for drug discovery.
• Toxicology Studies: Employed as a reference standard in marine toxin research and for understanding the mechanisms of action of cnidarian venoms.
• Biomarker Development: Potential use in developing diagnostic or detection methods for specific ion channel-related pathologies.
• Academic & Institutional Research: Essential reagent for universities and research institutes conducting fundamental studies in cellular signaling and neurobiology.

Basic Information

Product Name	Toxin Iii (Anemonia Sulcata)
CAS No.	60748-46-1
Molecular Formula	C184H274N52O53S7 (Representative)
Molecular Weight	~4,800 Da (Approximate)
Synonyms	ATX III; Anemonia sulcata Toxin III; Sea Anemone Toxin III; Sodium Channel Neurotoxin ATX III; Neurotoxin III (Anemonia sulcata); ASC III; ATX-III; Anemone Toxin III
EINECS	Contact for details

Quality Control

Every batch of Toxin Iii (Anemonia Sulcata) is produced and analyzed under stringent quality protocols to ensure identity, purity, and biological activity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific activity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Protein Content)	≥ 90% (by UV absorbance)
Specific Activity	Defined by biological assay (e.g., IC50 on NaV channels)
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 1.0 EU/µg (for cell culture grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.