Description

L-Proline Benzyl Ester Hydrochloride is a protected amino acid derivative widely used as a key chiral building block in organic synthesis. This compound is essential for the production of complex peptides and peptidomimetics, offering high purity and reliable stereochemical integrity. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly for creating novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediates: A crucial chiral synthon for the synthesis of peptide-based drugs, protease inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected proline residue in solid-phase and solution-phase peptide synthesis (SPPS) to construct complex peptide sequences.
• Biochemical Research: Used in academic and industrial R&D for studying enzyme-substrate interactions, protein folding, and as a standard in analytical method development.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to induce chirality in target molecules.
• Prodrug Development: Utilized in the design and synthesis of prodrugs where the benzyl ester group acts as a cleavable protecting group.

Basic Information

Product Name	L-Proline Benzyl Ester Hydrochloride
CAS No.	60668-01-1
Molecular Formula	C₁₂H₁₅NO₂·HCl
Molecular Weight	241.71 g/mol (Free base: 205.25 g/mol)
Synonyms	L-Proline benzyl ester HCl; (S)-(-)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid hydrochloride; Proline benzyl ester hydrochloride; H-Pro-OBzl·HCl; Benzyl L-prolinate hydrochloride; Pro-OBzl·HCl; (S)-Pyrrolidine-2-carboxylic acid benzyl ester hydrochloride; N-Cbz-L-Proline benzyl ester hydrochloride (Note: Common misnomer, structure differs)
EINECS	Contact for details

Quality Control

Our L-Proline Benzyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-60° to -65° (c=1 in methanol)
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.